Before you start choosing your dream holiday, it's best to start by identifying the practicalities. Not just financially but in terms of time and simplicity.
If you have a week's break, then following the Old Silk Road in Marco Polo's footsteps is probably not possible, though you might be able to catch a glimpse of it in China.
Crucially you want to identify what you want to experience on your vacation, and make sure it's practical.
Ask yourself: Where do you want to go?